Envoplakin IgG antibodies

Indication

Detection of Anti-Envoplakin (IgG) antibodies are intended for diagnostic of PNP (paraneoplastic pemphigus) which is a serious dermatosis associated with an underlying malignant disease - especially lymphoproliferative diseases non-Hodgkin's lymphoma and CLL (chronic lymphocytic leukemia).

Method

Serum samples are analyzed by ELISA technique.

Answer

The result is given as positive or negative.

Reference range

< 1.00 negative and ≥ 1.00 positive

Interpretation

PNP can occur prior to the manifestation of malignancy why suspected PNP always is followed by investigation of malignant disease. Antibody concentrations correlate with disease activity and may be used to monitor treatment efficacy.

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References

Probst C. et al., 2009. Clin Chim Acta. Development of ELISA for the specific determination of autoantibodies against envoplakin and periplakin in paraneoplastic pemphigus.

Baum S. et al, 2014. Autoimmun Rev. Diagnosis and classification of autoimmune blistering diseases.

Schmidt E. and Zillikens D., 2011.Dtsch Arztebl Int. The diagnosis and treatment of autoimmune blistering skin diseases.

Packages and other tests

View other packages Pemphigus/Pemphigoid (Bullous dermatosis) (550)

20 years experience