HMGCR antibodies

Indication

Suspicion of immune-mediated necrotizing myopathy (IMNM). Anti-HMCGR is strongly associated with previous statin therapy.

Method

CLIA

Response

The test result is given as negative or positive with a value.

Interpretation

Antibodies against HMG-CoA reductase (HMGCR) are associated with necrotizing autoimmune-myopathy and can be detected in up to 25% of these patients. Often it is seen greatly increased levels of creatine kinase (CK) in blood. Pronounced proximal muscle weakness is typical while lung involvement is less common. Almost half of the cases have previous treatment with statins. The level of anti-HMGCR is well correlated to the muscle strength and level of creatine kinase (CK) in blood. Anti-HMGCR-associated myositis often respond well to immunosuppressive therapy. Anti-HMGCR is usually not detected in healthy subjects or in subjects with other inflammatory and autoimmune diseases. Concurrent occurrence of autoantibodies against SRP (signal recogition particle) may occur in occasional cases and is prognostically unfavorable.

HMG-CoA reductase is an enzyme that catalyzes the reaction between HMG-CoA and mevalonic acid in the new synthesis of cholesterol. The discovery of HMG-CoA reductase inhibitors, also known as statins, was a breakthrough in the treatment of hypercholesterolemia. Statins are used to block the complex biosynthesis of cholesterol.

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References

Musset L et al., J Immunol Res. 2014; 2014:405956. PMID: 24741598

Allenbach et al, Medicine (Baltimore). 2014 May;93(3):150-7. PMID: 24797170

Drouot et al, Arthritis Res Ther. 2014 Feb 3;16(1): R39. PMID: 24484965

Hamann et al. Autoimmun Rev. 2013 Oct;12(12):1177-81. PMID: 23851103

Mohassel and Mammen, Curr Opin Rheumatol. 2013 Nov;25(6):747-52. PMID: 24061077

Mammen AL et al., Arthritis Rheum. 2011 Mar;63(3):713-21. PMID: 21360500

Packages and other tests

View other packages Inflammatory Myopathies (Myositis) (551)

20 years experience