Tau

Indication

Alzheimer's disease, memory examination, CNS parody injury.

Reference range

Reference range for Tau in CSF at different age intervals:

1 year - < 18 years: 250 ng/L
18 years - <45 years: <300 ng/L
>=45 years: < 400 ng/L
 

Interpretation

Total Tau reflects axonal decomposition. Tau occurs most in cortical omyelinated axon where they bind to microtubules with stabilizing effect. Tau can be phosphorylated to varying degrees (Phospho-Tau). Total Tau is used as a biomarker for Alzheimer's disease, but an increased level can also be seen in other degenerative central nervous system and stroke. The highest levels are seen in Creutzfeldt-Jakob's disease with rapidly progressive cortical degeneration.

Alzheimer's: Moderate to implemented powerful increased (sensitivity to detect Alzheimer's is 85%) Large acute stroke: Very sharply increased CJD: Very sharply increased Frontotemporal dementia: Normal / slightly increased Lewy body dementia: Normal / slightly increased Vascular dementia: Normal / slightly increased ALS: Normal

Normal aging, MCI (Mild cognitive impairment) without progression to Alzheimer's, depression, Parkinson, non-acute cerebrovascular disease show normal levels of total Tau.

Read more about sampling

Packages and other tests

View other packages CNS -Parenchymal damage (566). View other tests Beta-Amyloid, Phospho-tau

Acute test