Zic4 antibodies

Indication

Suspicion of paraneoplastic syndromes small cell lung cancer (SCLC).

Method

Immunoblot.

Accredited analysis for serum samples – read more at the Quality page.

Answer

Serum: The result is reported as negative or positive with a value (blot intensity).

CSF: The result is reported as negative or positive

Interpretation

Antibodies against Zic4 may occur with paraneoplastic neurological disease associated to small cell lung cancer with or without neurological symptoms. Most Zic4 positive patients also produce antibodies against Hu and CV2. Patients who have only Zic4 antibodies usually display symptom of cerebellar degeneration. Patients with a combination of Zic4 and other autoantibodies suffers from a broader spectrum of symptoms.

Read more about sampling

References:

PMID: 15342008: 15258215: 21747075: 22448032

Packages and other tests

View other packages Paraneoplastic Syndromes and Limbic Encephalitis (560, 561 and 562)

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