SOX1 antibodies

Indication

Suspicion of paraneoplastic syndrome and ambiguous forms of neuropathy.

Method

Immunoblot.

Accredited analysis for serum samples – read more at the Quality page.

Answer

Serum: The result is reported as negative or positive with a value (blot intensity).

CSF: The result is reported as negative or positive

Interpretation

Antibodies against SOX1 (or anti-glial nuclear antibody, AGNA) are unusual but have been reported to occur in paraneoplastic neuropathy, Lambert-Eaton syndrome and in unclear forms of neuropathy and ataxia. SOX1 antibodies are often associated with antibodies against VGCC, Hu, CV2 / CRMP5 or amphiphysin. The most common cancer form associated with SOX1 is small cell lung cancer, but other lung cancer forms have also been reported.

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References:

Stich et al. Acta Neurol Scand. 2012;125(5):326-31.

Lancaster et al. Neurology. 2011;12;77(2):179-89.

Zuliani et al. J Neurol Neurosurg Psychiatry. 2012;83(6):638-45.

Tschernatsch et al. Autoimmun Rev. 2009 Jun;8(7):549-51.

Packages and other tests

View other packages Lambert-Eatons myastena syndrom (LEMS) (563), Paraneoplastic Syndromes and Limbic Encephalitis (560, 561 and 562). View other tests AMPA receptor 1 and 2 (GluR1 and GluR2) antibodies, Amphiphysin antibodies, CASPR2 antibodies, CV2/CRMP5 antibodies, DPPX (dipeptidyl aminopeptidase-like protein 6) antibodies, GABA B receptor antibodies, GAD antibodies, LGI-1 antibodies, Ma (Ma-2/Ta) antibodies, NMDA receptor antibodies, Purkinje cell antibodies (Tr, Trotter antigen), Recoverin antibodies, Titin antibodies, VGKC (voltage gated potassium channel) antibodies, Yo (PCA-1, Purkinje cells antigen 1) antibodies, Zic4 antibodies

Acute test