Ryanodine receptor antibodies

Indication

Suspected thymoma and myopathy.

Method

Immunoblot.

Answer

The result is given as negative or positive.

Interpretation

Ryanodine receptors (RyR) is one of the most important mediators of calcium release in muscle cells as well as one of the most important steps in muscle contraction. There are several isoforms of ryanodine receptors. RYR1 is expressed primarily in striated muscle, while RyR2 is expressed mainly in myocardium. Anti-RyR1 antibodies detected by thymoma and myopathy and in connection with myasthenia gravis (MG).

Generally, treatment with immunotherapy are more effective against auto-antibodies directed to extracellular antigen than with auto-antibodies against intracellular antigens.

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