VGCC (voltage-gated calcium channel) antibodies

Indication

Suspicion of paraneoplastic neuropathy, Lambert-Eaton myasthenic syndrome and cerebellar dysfunction.

Method

Radioimmunoprecipitation (RIA).

Answer

The answer given as a ratio for VGCC N-type antibodies)

The answer is given as pmol / L for P/Q type antibodies.

Interpretation

Calcium channel antibodies occur in paraneoplastic neuropathy in e.g. small cell lung cancer, but even without this association. Causes include Lambert-Eaton myasthenic syndrome and cerebellar dysfunction. It is primarily the VGCC P/Q type antibodies that are of clinical significance while the importance of VGCC N-type antibodies is less known.

Generally, treatment with immunotherapy is more effective against auto-antibodies directed to extracellular antigens than with auto-antibodies against intracellular antigens.

Read more about sampling

References:

PMID: 15342008: 15258215: 21747075: 22448032

Packages and other tests

View other packages Lambert-Eatons myastena syndrom (LEMS) (563), Paraneoplastic Syndromes and Limbic Encephalitis (560, 561 and 562). View other tests VGKC (voltage gated potassium channel) antibodies

Acute test