Beta-2 Glycoprotein-1 antibodies - IgG and IgM

Indication

Suspected autoimmune arterial and / or venous thrombosis, thrombocytopenia, and repeated abortions. This is seen in primary antiphospholipid syndrome (APS) and systemic lupus erythematous with secondary anti-phospholipid syndrome (APS).

Method

The analysis is performed by ELISA. Answers are given both in IgG and IgM antibodies.

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Answer

The result is given as negative, borderline or positive with a value.

Interpretation

Elevated levels of antibodies against ?2-Glycoprotein-1 at two sampling occasions with at least 12 weeks interval is a marker for the anti-phospholipid syndrome (APS) that is characterized by recurrent arterial and/or venous thrombosis, and/or recurrent miscarriages. APS is often associated with SLE (secondary APS) but may also be seen without associated inflammatory disease (primary APS).

If suspicion of antiphospholipid syndrome (APS) remains despite negative results regarding the classical antiphospholipid associated antibodies (lupus anticoagulant (LA), IgG- and/or IgM-antibodies against beta2-Glycoprotein-1 and cardiolipin), IgA-antibodies against cardiolipin/ beta2-Glycoprotein-1 support the APS-diagnosis in isolated cases. In addition, antibodies against phosphatidylserine can be of value.

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Packages and other tests

View other packages Antiphospholipid syndrome (APS) (510). View other tests ANA screen (HEp-2 cells), ANCA IIF, Cardiolipin antibodies – IgG and IgM, dsDNA antibodies, MPO-ANCA (capture technique), MPO-ANCA (direct technique), PR3-ANCA (capture technique), PR3-ANCA (direct technique)

Acute test