Yo (PCA-1, Purkinje cells antigen 1) antibodies

Indication

Suspicion of paraneoplastic syndrome.

Method

Immunoblot and indirect immunofluorescence (IIF). For IIF test it is applied a combination of fixed tissues from the nerve, cerebellar, intestinal tissue and pancreas originating from monkeys.

According to guidelines, anti-neuronal antibodies should be detected by at least two independent methods. At Wieslab IIF and immunoblot are used. According to European guidelines, a positive result should be obtained with both methods to be reliable. According to the supplier the assay sensitivity is 100% and specificity is 100%.

Immunoblot and IIF are accredited analysis for serum samples – read more at the Quality page.

Result

Serum: The result is reported as negative or positive with a titer and blot intensity.

CSF: The result is reported as negative or positive

Interpretation

Antibodies against Yo are also called anti-PCA-1 (Purkinje cells antigen 1) and are strongly associated with subacute cerebral ataxia at ovarian or breast cancer. Neuropathy can also occur. Neurological symptoms may precede the diagnosis of cancer with up to five years.

Accredited analysis – read more at the Quality page.

Read more about sampling

References:

PMID: 15342008: 15258215: 21747075: 22448032

Packages and other tests

View other packages Paraneoplastic Syndromes and Limbic Encephalitis (560, 561 and 562). View other tests ANNA-3 antibodies, CARP VIII antibodies, Glycine receptor (GlyR) antibodies, HOMER 3 antibodies, IgLON5 antibodies, ITPR1 antibodies, VGCC (voltage-gated calcium channel) antibodies

Clinical studies