Ma (Ma-2/Ta) antibodies

Indication

Suspicion of paraneoplastic syndrome.

Method

Immunoblot and indirect immunofluorescence (IIF). The antigen for the immunoblot is produced and purified by biochemical methods. The indirect immunofluorescence (IIF) test is a combination of fixed tissues from the nerve, cerebellar, intestinal tissue and pancreas originating from monkeys. In cerebrospinal fluid only the immunoblot test is done.

Result

The test result is expressed as negative or positive. IIF followed up by answers in titer and immunoblot is followed up by answers with intensity. For CSF the answer is either positive or negative.

Interpretation

Results for paraneoplastic antibodies should be verified by both analyzes to provide a comprehensive response according to European guidelines.
 
According to the supplier the assay sensitivity is 89% and specificity is 100%.
 
Ma-2 antigen is found in neurons and testis. Ma-2 also known as Ta. In the past, anti-Ma-1 antibodies have also been analyzed, but as there has been no difference in the test result between MA-1 and MA-2 analyzes only Ma-2 is analyzed as it is considered relevant for paraneoplastic syndromes. The antibodies are associated with paraneoplastic cerebellar degeneration, limbic encephalitis and brain stem encephalitis. The antibodies can be present in many different cancers, e.g. breast cancer, testis cancer and small cell lung cancer. With the paraneoplastic syndrome patients often develop neurological symptoms before clinical manifestations are caused by the tumor. In the treatment of paraneoplastic syndrome it is important to find the underlying tumor and treat it. Generally, treatment with immunotherapy is more effective against auto-antibodies directed to extracellular antigen than with auto-antibodies against intracellular antigens.
 

References:

PMID: 15342008: 15258215: 21747075: 22448032

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Packages and other tests

View other packages Autoimmune encephalitis (Package 560, 561 and 562), Paraneoplastic Syndromes and Limbic Encephalitis (560, 561 and 562). View other tests AMPA receptor 1 and 2 (GluR1 and GluR2) antibodies, Amphiphysin antibodies, CASPR2 antibodies, CV2/CRMP5 antibodies, DPPX (dipeptidyl aminopeptidase-like protein 6) antibodies, GABA B receptor antibodies, GAD antibodies, Hu antibodies, LGI-1 antibodies, NMDA receptor antibodies, Purkinje cell antibodies (Tr, Trotter antigen), Recoverin antibodies, Ri (Nova 1/ ANNA-2) antibodies, SOX1 antibodies, Titin antibodies, VGKC (voltage gated potassium channel) antibodies, Yo (PCA-1, Purkinje cells antigen 1) antibodies, Zic4 antibodies

Clinical studies