Sm antibodies

Indication

Sm antibodies are included in the analysis ENA screen. See therefore “ENA screen” for indication, method, answer and reference range.

Interpretation

Positive in 10-30% of patients with SLE in Western Europe. The specifi city is high for this disease. The frequency is considerably higher in Afro-Americans and Asians with SLE than in Caucasians. Sm is a nuclear non-histone protein. SLE patients often remain positive for Sm in remission and therefore detection of Sm may be valuable, when anti-dsDNA cannot be measured.

Read more about sampling

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