PR3-ANCA (direct technique)

Indication

Suspicion of systemic vasculitis and follow-up of patients with vasculitis.

Method

Direct ELISA with granulocyte proteinase 3 (PR3) as antigen.

Accredited analysis – read more at the Quality page.

Answer

The result is given as international units (IU/ml).

Interpretation

Anti-neutrophil cytoplasmic antibodies (ANCA) are a family of autoantibodies with specificity for different antigens in the neutrophil granulocytes’ granules.

PR3-ANCA is a marker for granulomatosis with polyangiitis (GPA) that previously was named Wegener granulomatosis. In the active phase of the disease about 90% of the patients are positive for PR3-ANCA. Studies have shown that the antibody level decreases and often becomes negative when the disease is in remission. A rising level may indicate a relapse. As a rule it does not occur in healthy people but can rarely be detected (usually low levels) in infections.

Read more about sampling

Packages and other tests

View other packages ANCA for Systemic Vasculitis/anti-GBM Goodpastures syndrome (501), Glomerulonephritis (500), Sudden deafness (530), Systemic vasculitis – acute screening (009), Systemic vasculitis – follow-up (504,505)

20 years experience