Myelin oligodendrocyte glycoprotein (MOG) antibodies

Indication

Suspicion of Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO).

Method

Indirect immunofluorescens (IIF) in cells transfected with MOG.

Answer

Results are given as positive or negative. A positive result is followed by a titer (serum).

Interpretation

Myelin oligodendrocyte glycoprotein is expressed on the myelin sheath. Increased levels of antibodies against MOG may occur at very low frequency in multiple sclerosis but should be tested in anti-aquaporin 4-negative patients where Neuromyelitis optica/Neuromyelitis optica spectrum disorders (NMO/NMOSD) is suspected.

Detection of antibodies against MOG has been found to be more sensitive in serum when compared to CSF. In patients with high levels of anti-MOG antibodies in blood, they can sometimes also be detected in CSF, suggesting passage of the antibodies from blood across the blood-brain barrier. The significance of anti-MOG antibodies in CSF is unclear.

Read more about sampling

Packages and other tests

View other packages Multiple Sclerosis / Neuromyelitis optica (Devic’s syndrome) (565). View other tests Aquaporin 4 antibodies (NMO)

20 years experience