MPO-ANCA (direct technique)

Indication

Suspicion of systemic vasculitis, especially with kidney involvement.

Method

Direct ELISA with granulocyte myeloperoxidase (MPO) as antigen.

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Answer

The result is given as international units (IU/ml).

Interpretation

MPO-ANCA is a marker for the vasculitis diseases granulomatosis with polyangiit (GPA), previously named microscopic polyangiitis, and eosinophil granulomatosis with polyangiitis (EGPA), previously named Churg-Strauss syndrome. Antibodies level may decrease during remission and an increasing level may suggest recurrence. MPO-ANCA may also occur in SLE, infections and drug induced conditions without relation to vasculitis.

Read more about sampling

Packages and other tests

View other packages ANCA for Systemic Vasculitis/anti-GBM Goodpastures syndrome (501), Glomerulonephritis (500), Systemic vasculitis – acute screening (009), Systemic vasculitis – follow-up (504,505). View other tests ANCA IIF, ANCA – panel, MPO-ANCA (capture technique), PR3-ANCA (capture technique), PR3-ANCA (direct technique)

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