Islet cell antibodies

Indication

Suspicion of risk of developing type 1 diabetes (T1D, previously known as insulin-dependent diabetes mellitus IDDM). The marker may be used for early diagnosis of T1D in both young and old people.

Method

Indirect immunofluorescence.

Answer

The result is given as negative, weak, medium or strong positive.

Interpretation

At the time of diagnosis of insulin-dependent diabetes mellitus (IDDM), antibodies against Langerhanska islet cells can be detected in 70-90% of the patients. Antibodies may occur several years prior to clinical diabetes and are a strong predictor for future development of the disease.

Islet cell antibodies constitute a heterogeneous group of antibodies that may be directed to glutamic acid decarboxylase (GAD65), tyrosine phosphatase-related islet cell antigen 2 (IA-2), zinc transport protein ZnT8 or other so far unknown antigens.

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Packages and other tests

View other packages Diabetes (531). View other tests GAD antibodies, IA-2 antibodies, Insulin antibodies

Acute test