Intrinsic factor antibodies

Indication

Suspicion of pernicious anemia or Atrophic gastritis (autoimmune metaplastic athrophic gastritis = AMAG).

Method

Radioimmunoprecipitation with recombinant antigen.

Answer

The result is given as a ratio between patient serum and normal serum.

Interpretation

Intrinsic factor antibodies occur in 50-80 % of cases with pernicious anemia but also in an inherited form of atrophic gastritis – autoimmune metaplastic atrophic gastritis (AMAG) when the immune response is directed against parietal cells and intrinsic factor. The antibodies can either block the binding of vitamin B12 to intrinsic factor or block the receptor.

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