Histone antibodies

Indication

Suspicion of drug induced lupus syndrome.

Method

ELISA with a mixture of histones as antigen. The antibodies are directed against strongly basic proteins that are closely associated with DNA in the chromatin of the cell nucleus and are called H1, H2A, H2B, H3 and H4.

Answer

The result is given as positive or negative.

Reference range

<20 RU/ml negative, ≥20 RU/ml positive

Interpretation

Positive in about 95% of patients with drug induced LE syndrome, usually after long-term use of procainamide and hydralazine. Also positive in 30-40% of patients with systemic lupus erythematosus, where the antibodies are mainly directed against H1 and H2B and in about 20% of patients with rheumatoid arthritis, in particular in patients who develop rheumatoid vasculitis.

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Packages and other tests

View other packages Drug induced lupus (541). View other tests ANA screen (HEp-2 cells), ANCA IIF, Cardiolipin antibodies – IgG and IgM

20 years experience