Ganglioside antibodies – IgG and IgM

Indication

Suspicion of Inflammatory neuropathy.

Method

ELISA with detection of IgG and IgM antibodies against ganglioside antigens GM1, GM2, GD1a, GD1b, GQ1b.

Answer

The result is given as negative or positive with a value.

Interpretation

Gangliosides are a group of glycosphingolipids which are enriched neuronal plasma membranes and are involved in signal transduction. Antibodies against many different types of gangliosides are associated with sensor and motor neuropathies. There are many gangliosides, but GM1, GM2, GD1a, GD1b and GQ1b are those commonly associated with autoantibodies.

Antibodies against multiple gangliosides can often be detected simultaneously due to cross-reactivity as result of their high molecular similarity. Low levels of antibodies against gangliosides may occur without disease association and may be transiently seen after infections.

Read more about sampling

Packages and other tests

View other packages Inflammatory neuropathy (Guillain-Barré) (534). View other tests Myelin associated glycoprotein (MAG) antibodies, Sulfatide IgM

Clinical studies